Senior Scientist, In vivo Pharmacology, Oncology Targeted Discovery

Senior Scientist, In vivo Pharmacology, Oncology Targeted Discovery

Are you passionate about oncology research and development? Do you want to contribute to life-changing medicines by following the science? Join AstraZeneca as a Senior Scientist in our Oncology Targeted Discovery group in Waltham, Massachusetts. We are looking for a motivated and independent scientist with a proven track record in cancer pharmacology. In this role, you will be instrumental in delivering in vivo pharmacology support, establishing mouse models, and providing critical datasets that impact our drug discovery pipeline.

Accountabilities:

In this laboratory-based position, you will design, execute, and interpret in vivo and ex vivo experiments to evaluate the activity and mechanisms of action of oncology drug candidates. Your research will provide mechanistic insights and efficacy data essential for developing novel therapeutics. Collaborate with cross-functional teams and project leaders to ensure timely delivery and communication of program data. Support scientific publication objectives and stay updated on advances in tumor biology, pharmacology, and cancer modeling.

Essential Skills/Experience:

- A PhD with at least two years or a BS/MS with at least five years of relevant research experience in biology, pharmacology, or a related scientific discipline is required.
- Significant hands-on experience developing and working with advanced in vivo oncology models, including subcutaneous xenograft, patient-derived xenograft (PDX), syngeneic, disseminated, and PBMC/HSC humanized mouse models.
- Direct experience conducting in vivo pharmacology studies using mouse tumor models - including dose-finding, tolerability, pharmacokinetics/pharmacodynamics (PK/PD), and efficacy studies - is essential.
- Adept at various routes of dosing administration, such as intravenous (IV), intraperitoneal (IP), and oral gavage (PO).
- Solid foundation in in vitro techniques, such as cell culture, molecular biology, immunoblotting, flow cytometry, and ELISA/MSD.
- Ability to work independently, critically analyze and report data, and interpret experimental findings within the broader landscape of drug discovery.
- Strong understanding of drug discovery processes and ability to apply cross-functional knowledge to support diverse project teams.
- Excellent interpersonal and collaboration skills, with the ability to communicate findings clearly and confidently in both written and oral formats.

Desirable Skills/Experience:

- Previous experience in the biotechnology or pharmaceutical industry, especially within oncology.
- Familiarity with in vivo studies involving antibody-drug conjugates (ADCs), combination therapy approaches, and therapy-resistant or immuno-oncology mouse models.
- Experience designing, executing, and analyzing multi-spectral flow cytometry for immune phenotyping.
- Experience training and mentoring junior scientists.
- Thorough knowledge of the industrial drug discovery process.

At AstraZeneca, we are united by our vision to eliminate cancer as a cause of death. Our team is at the forefront of applying science to transform cancer treatment and improve patient outcomes. With one of the broadest oncology pipelines in the industry, we offer opportunities to work with novel drugs and innovative approaches. Our collaborative environment fosters learning from diverse perspectives and empowers individuals to take smart risks. Join us to be part of a global team dedicated to making a meaningful difference for patients worldwide.

Ready to make an impact? Apply now to join our team!

The annual base pay for this position ranges from $108,473.60 - 162,710.40. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.  In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. 

Date Posted

29-Oct-2025

Closing Date

13-Nov-2025

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.